Born in Nablus in 1909 and the brother of Adel Zuaiter, Akram Zuaiter completed his studies at An-Najah College before enrolling at the Jerusalem School of Law, where he graduated with a Law Certificate. He worked as a teacher in Nablus and Acre from 1926-29, but resigned when he got increasingly involved in the Palestinian national movement. He was head of the Editing Department of the Jerusalem-based Mirat Ash-Sharq (Mirror of the East) newspaper, owned by Boulos Shehadeh, in 1929-30. He was arrested in 1931 by the British authorities for his criticism of British pro-Zionist politics and was prevented from leaving Nablus for one year. In 1932 he became a founding member of the Istiqlal Party and supervised its branches. He was appointed as a teacher at Dar Al-Mu’allamin (Teacher's College) in Baghdad from 1933-35, then returned to Palestine and helped establish national committees. Zuaiter also became treasurer of the national committee in Nablus and participated in the Arab Revolt in 1936 for which he was detained by the British.
He subsequently spent the years 1937-1951 in exile and moved to Iraq, where he worked as a teacher and an inspector. In 1941 he participated in Rashid Ali Kilani's revolt in Iraq, later moving to Aleppo, Syria, and then to Turkey for three years after the revolt was suppressed. He returned to Syria where he participated in national activities and was selected head of the Arab Delegation that went to Latin America in 1947 to explain and lobby for the Palestinian cause. He became a counselor of the Syrian government in the Permanent Palestine Committee before returning to Palestine in 1951.
He was Secretary-General of the Islamic Conference, which convened in Jerusalem in 1959. He was appointed Ambassador of Jordan in Damascus from 1963-64 and later Ambassador in Iran. He was appointed Minister of Foreign Affairs, then member of the House of Senates in 1966, and later appointed Minister of the Royal Hashemite Court in 1967. In 1968, he became Ambassador at the Ministry of Foreign Affairs and served as Ambassador in Beirut and Athens from 1971 to 1975. During his stay in Lebanon, he was head of the Islamic Cultural Center until he left Beirut following the Israeli siege in 1982, during which his library was burnt. He went back to Jordan and became a member of the House of Senates and in 1984 he was appointed as the head of the Royal Committee for Jerusalem Affairs in Amman. Zuaiter edited and wrote several books on Palestine including The Palestine Question (English, Damascus, 1958), Documents on the Palestinian National Movements, 1918-1939 and 1935-1939 and My Memories.
He died in Amman on April 11, 1996.